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Due to its highly effective ability to harden platinum and palladium, ruthenium is used in Pt and Pd alloys to make severe wear-resistant electrical contacts. It is sometimes alloyed with gold in jewelry.

0.1% ruthenium is added to titanium to improve its corrosion resistance a hundredfold.

Ruthenium will also be used in some advanced high-temperature single-crystal superalloys, with applications including the turbine blades in jet engines.

Fountain pen nibs are frequently tipped with alloys containing ruthenium. From 1944 onward, the famous Parker 51 fountain pen was outfitted with the "RU" nib, a 14K gold nib tipped with 96.2% ruthenium, and 3.8% iridium.

Ruthenium is also a versatile catalyst: hydrogen sulfide can be split by light by using an aqueous suspension of CdS particles loaded with ruthenium dioxide. This may be useful in the removal of H2S from oil refineries and from other industrial processes.

Organometallic ruthenium carbene and allenylidene complexes have recently been found as highly efficient catalysts for olefin metathesis with important applications in organic and pharmaceutical chemistry.

Some ruthenium complexes absorb light throughout the visible spectrum and are being actively researched in various, potential, solar energy technologies.

The fluorescence of some ruthenium complexes is quenched by oxygen, which has led to their use as optode sensors for oxygen.

Ruthenium red, [(NH3)5Ru-O-Ru(NH3)4-O-Ru(NH3)5]6+, is a biological stain used to visualize polyanionic areas of membranes.

Ruthenium-centered complexes are being researched for possible anticancer properties. Ruthenium, unlike traditional platinum complexes, show greater resistance to hydrolysis and more selective action on tumors. NAMI-A and KP1019 are two drugs undergoing clinical evaluation against metastatic tumors and colon cancers.

Ruthenium was discovered and isolated by Russian scientist Karl Klaus in 1844. Klaus showed that ruthenium oxide contained a new metal and obtained 6 grams of ruthenium from the part of crude platinum that is insoluble in aqua regia.

Jöns Berzelius and Gottfried Osann nearly discovered ruthenium in 1827. The men examined residues that were left after dissolving crude platinum from the Ural Mountains in aqua regia. Berzelius did not find any unusual metals, but Osann thought he found three new metals and named one of them ruthenium.

The name derives from Ruthenia the Latin word for Rus', a historical area which includes present day Ukraine, Belarus, and parts of the Russia, Baltics, Slovakia and Poland. Karl Klaus called the element in honour of his birthland. He was born in Tartu, Estonia, then part of the Russian Empire.

It is also possible that Polish chemist Jedrzej Sniadecki isolated element 44 (which he called vestium) from platinum ores in 1807. However his work was never confirmed and he later withdrew his discovery claim.